Lactyltransferases, such as p300, CBP, and TIP60, can catalyze the transfer of the lactyl group from lactyl-CoA to the lysine residues of target proteins [25]
This suggestion was further insisted as a potential mechanism of TB-500 by the authors of the research study, who also commented that " transfection of anti-miR-146a nucleotides reversed the inhibitory effect of T4 on IRAK1 and TRAF6
The ESI source conditions were set as following: sheath gas flow rate of 50 arbitrary units (Arb), auxiliary gas flow rate of 15 Arb, capillary temperature of 320 C, full MS resolution of 60,000, MS/MS resolution of 15,000, collision energy of 10/30/60 in normalized collision energy (NCE) mode, and spray voltage of 3.8 kV (positive) or 3.4 kV (negative)
Liu H, Forouhar F, Seibt T, Saneto R, Wigby K, Friedman J, et al